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“I participate because it is the right thing to do, for myself, for my children, and for the millions of people who have Parkinson’s disease. Without participation there will be no cure.” –Mike, Diagnosed 7 years
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If you have recently been diagnosed with Parkinson’s disease (PD) understanding the disease, and learning about the resources available to you, are good first steps.
Colonoscopic Screening for Autonomic Pathology in Parkinson's Disease
Official Study Title: Colonoscopic Screening ScreeningPeriod of selection of clinical trial participants based on ELIGIBILITY CRITERIA. for Autonomic Pathology in Parkinson’s Disease
Sponsor: University of Utah
Clinicaltrials.gov ID:
Study ID:
Summary
The purpose of this study is to determine whether the abnormal protein build-up seen in the brains of people with Parkinson's disease Parkinson's DiseaseA chronic, slowly progressive disease of the nervous system characterized by the combination of tremor, rigidity, bradykinesia and stooped posture, among other symptoms. (PD) and dementia DementiaA decline in higher-level brain functions, such as memory, reasoning and personality. with Lewy bodies (DLB) is also present in the nerves that line the intestine.
This information would guide future research designed to diagnose people at the earliest stage of these diseases. Such information could help with research on new therapies designed to slow progression of (or even prevent) PD and DLB. This study will recruit participants with PD or DLB, as well as people (over age 50) who do not have a neurologic condition.
To participate, a person needs have been referred by their doctor to the University of Utah for colonoscopy (current recommendations are that all people over age 50 have this test once every ten years to screen for colon cancer). This study is enrolling a total of 70 participants.
Study Phase
Not Applicable
What is a study phase?
Symptoms Addressed: Study does not address symptoms
Study does not address symptoms
Time Commitment
- Less than one day
- One visit
Eligibility
- Minimum Age: 50
- Gender(s) Accepted: Either
- Study is enrolling non-PD participants
Inclusion Criteria
A total of 15 Parkinson’s disease participants (10 with disease duration less than 5 years and 5 with duration longer than 5 years), 5 dementia with Lewy body participants, 15 with unexplained diarrhea or constipation (no neurologic disease), and 35 non-PD participants will be enrolled.Exclusion Criteria
Non-PD volunteers will be excluded from participating as controls if they have any history of a neurologic disorder, or are found with a screening examination to have evidence of parkinsonism (tremor, TremorShaking or rhythmic movement, especially in the hands but in other parts of the body. Often occurs when at rest, such as in the RESTING TREMOR. bradykinesia, BradykinesiaSlowness of movement. or rigidity) RigidityA symptom in which muscles feel stiff and display resistance to movement even when another person tries to move the affected part of the body. .Enrollment
Expected Enrollment: 70 (US)
Date Enrollment Began: Mar 2010
Date Enrollment Ends: Jun 2011
Last Updated Date: Mar 17 2010
Trial Post Date: Mar 15 2010
Website:
Primary Contacts and Locations
Utah
- Paola Wall — Study Coordinator
University of Utah Department of Neurology
Paola.wall@hsc.utah.edu
Phone: (801) 581-4543
729 Arapeen Drive
Salt Lake City, UT 84108
USA
